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Anesthesia in Closed Loop

Researchers: Tore Hägglund (area leader) and Kristian Soltesz in collaboration with professor Guy Dumont and the ECEM group, University of British Columbia, Vancouver, Canada.

Results: After being an LCCC seedproject (24 months), the research became part of the department's biomedical projects and the results published in a PhD thesis.

Acknowledgement: The project would not have been possible to perform without the support from LCCC.

Objective: To develop an automatic control system for anesthesia

Description: Computer controlled, or automatic, drug delivery is the process of administering a therapeutic regime to a patient with computer assistance for calculation of optimal dose and delivery schedules. Computer control can improve drug therapy by reducing drug usage and costs, by permitting health care staff to work more efficiently and to provide better standard of care, by allowing the safe use of drugs that are difficult to administer, and by compensation for human failings with computer strengths, such as unlimited attention span and patience, and capacity for quick, accurate and redundant calculation.

Our goal is to develop an automatic control system for anesthesia and to demonstrate its efficacy, safety and benefits in an operating room. Although closed-loop anesthesia has previously been proposed and tested, it has yet to have a significant impact on clinical practice. Recent developments in sensing for anesthesia have opened new possibilities for closing the loop. Our research will focus on the deployment of new sensors optimized for controlled drug delivery, robust control methodology and extensive clinical validation.

Clinical partner in the project is the Department of Anesthesia at the British Columbia Children's Hospital (BCCH), Vancouver, Canada, where patient modeling data is collected and clinical trials of the control system are conducted.

A PID controller based drug delivery system for depth of hypnosis control was evaluated in a patient study (BCCH REB approval H10-01174)  during 2011.

Our current aim is to extend the system to control hypnosis and analgesia simultaneously, by adding a second drug.

 

Publications

Kristian Soltesz, Pedro Mercader: "Identification for Control of Biomedical Systems using a very Short Experiment". In 2016 International Conference on Systems in Medicine and Biology, 2016.

Kristian Soltesz, Klaske van Heusden, Martin Hast, J. Mark Ansermino, Guy A. Dumont: "A Synthesis Method for Automatic Handling of Inter-patient Variability in Closed-loop Anesthesia". In American Control Conference, 2016, 2016.

Klaske van Heusden, Guy A. Dumont, Kristian Soltesz, Christian L. Petersen, Aryannah Umedaly, Nicholas West, J. Mark Ansermino: "Design and clinical evaluation of robust PID control of propofol anesthesia in children". IEEE Transactions on Control Systems Technology, 22:2, pp. 491–501, 2014.

Kousha Talebian, Kristian Soltesz, Guy A. Dumont, J. Mark Ansermino: "Clinical Assessment of Control Performance in Closed-Loop Anesthesia". In American Society of Anesthesiologists (ASA) Annual Meeting, 2013.

Kristian Soltesz: On Automation in Anesthesia. PhD Thesis TFRT-1096, Department of Automatic Control, Lund University, Sweden, July 2013.

Kristian Soltesz, Guy A. Dumont, J. Mark Ansermino: "Assessing Control Performance in Closed-loop Anesthesia". In 21st Mediterranean Conference on Control and Automation, 2013.

Kristian Soltesz, Jin-Oh Hahn, Tore Hägglund, Guy A. Dumont, J. Mark Ansermino: "Individualized closed-loop control of propofol anesthesia: A preliminary study". Biomedical Signal Processing and Control, 8:6, pp. 500–508, 2013.

Nicholas West, Guy A. Dumont, Klaske van Heusden, Christian Petersen, Sara Khosravi, Kristian Soltesz, Aryannah Umedaly, Eleanor Reimer, J. Mark Ansermino: "Robust closed-loop control of induction and maintenance of propofol anesthesia in children". Paediatric Anaesthesia, 23:8, pp. 712–719, 2013.

Klaske van Heusden, J. Mark Ansermino, Kristian Soltesz, Sara Khosravi, Nicholas West, Guy A. Dumont: "Quantification of the variability in response to propofol administration in children". IEEE Transactions on Biomedical Engineering, 60:9, pp. 2521–2529, 2013.

Kristian Soltesz, Klaske van Heusden, Guy A. Dumont, Tore Hägglund, Christian Petersen, Nicholas West, J. Mark Ansermino: "Closed-Loop Anesthesia in Children using a PID Controller: A Pilot Study". IFAC Proceedings Volumes, 45:3, pp. 317–322, 2012.

Klaske van Heusden, Guy A. Dumont, Kristian Soltesz, Christian Petersen, Nicholas West, Aryannah Umedaly, J. Mark Ansermino: "Clinical Evaluation of Closed-Loop Administration of Propofol Guided by the NeuroSENSE Monitor in Children". In The Amerian Society of Anesthesiologists (ASA) Annual Meeting, 2012.

Klaske van Heusden, Guy A. Dumont, Kristian Soltesz, Christian Petersen, Nicholas West: "Clinical evaluation of closed-loop controlled propofol infusion in children". In: British Journal of Anaesthesia, 2012.

Kristian Soltesz, Guy A. Dumont, Klaske van Heusden, Tore Hägglund, J. Mark Ansermino: "Simulated Mid-ranging Control of Propofol and Remifentanil using EEG-measured Hypnotic Depth of Anesthesia". In 51st IEEE Conference on Decision and Control, 2012, 2012.

Kristian Soltesz, Jin-Oh Hahn, Guy A. Dumont, J. Mark Ansermino: "Individualized PID Control of Depth of Anesthesia Based on Patient Model Identification During the Induction Phase of Anesthesia". In 50th IEEE Conference on Decision and Control and European Control Conference, 2011, 2011.


2017-01-09