Hemodynamic Stabilization

Researchers: Kristian SolteszAnders Robertsson, Rolf Johansson, in collaboration with Igelösa Life Science AB.

Duration: 2016-18

Funding: VINNOVA through the Medtech4Health strategic innovation program


The aim of the project is to develop methods for hemoynamic stabilization of intensive  care patients. It comprises closed-loop control of readily measurable signals, including heart rate, arterial and venous blood pressure. Furthermore, the project aims at optimizing hemodynamic parameters, which are not directly measurable, such as cardiac outputm and responsiveness to volume expansion.

The aim of the project is to develop a generic platform for closed-loop intravenous drug delivery. Apart from being used in research, such a platform can be adapted to a multitude och medical treatment scenaraios, foremost in intensive care, where it has the potential to increase the availability of specialized physicians.

Hemodynamic stabilization system prototype, developed within the project.



The aim of the project is to provide physicians with an 'auto pilot' for hemodynamic stabilizatioin and optimization.

The initially considered patient group are heart-beating braindead patients under intensive care (potential organ donors). Due to the compelte loss of vasomotor center function, hormonal and fluid therapy is required to establish hemodynamic stability within this group.

We combine automatic control methods with medical insight, to develop closed-loop controlled therapies. Developed methods are implemented on our in-house developed control system comprising sensors for invasive blood pressure measurement, and urination rate, as well as syringe and volumetric infusion pumps for closed-loop controlled intravenous drug and fluid administration.

The methods are pre-clinically evaluated in collaboration with the project partner Igelösa Life Science AB. Following successful initial experiments, we are looking into clinical evaluation of some of the developed methods.


Kristian Soltesz: "Robust computation of pulse pressure variations". Biomedical Signal Processing and Control, 39, pp. 197–203, 2017.

Kristian Soltesz, Trygve Sjöberg, Tomas Jansson, Rolf Johansson, Anders Robertsson, Audrius Paskevicius, Qiuming Liao, Guangqi Qin, Stig Steen: "Closed-loop regulation of arterial pressure after acute brain death". Journal of Clinical Monitoring and Computing, 2017.

Kristian Soltesz, Christopher Sturk, Audrius Paskevicius, Qiuming Liao, Guangqi Qin, Trygve Sjöberg, Stig Steen: "Closed-loop Prevention of Hypotension in the Heartbeating Brain-dead Porcine Model". IEEE Transactions on Biomedical Engineering, 64:6, pp. 1310–1317, 2017.

Kristian Soltesz, Pedro Mercader: "Identification for Control of Biomedical Systems using a very Short Experiment". In: 2016 International Conference on Systems in Medicine and Biology 2016.